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张骆强

博士 副研究员
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基本情况

2014年和2019年于四川大学化学学院分别获得学士和博士学位,导师为游劲松教授。博士毕业后前往北京大学深圳研究生院为研究助理开展科研工作,合作导师为周建荣(Jianrong Steve Zhou)副教授。2021年开始在新加坡南洋理工大学进行博士后研究,合作导师为池永贵(Yonggui Robin Chi)教授。2023年11月加入四川大学华西公共卫生学院(华西第四医院)。同年入选四川大学“双百人才工程”B计划。

近年来主要在有机合成方法学领域开展研究,为药物分子提供高效合成新方法。迄今已发表SCI论文18篇,其中以第一(含共一)作者身份在J. Am. Chem. Soc.、ACS Catal.、Chem. Commun.、Org. Lett.等国际权威学术期刊上发表高水平论文7篇。

工作经历

2019/07-2021/02 北京大学深圳研究生院  研究助理
2021/03-2023/09 新加坡南洋理工大学  博士后

2023/11-至今 四川大学华西公共卫生学院(华西第四医院)  特聘副研究员

研究方向(含承担课题)

有机合成化学、药物化学。主要发展丰产过渡金属催化的不对称有机合成方法学,以实现对相关药物分子的高效合成、修饰和编辑,同时探索在毒理、生物活性构效关系研究等方面的应用。

科研成果

1. Luoqiang Zhang, Xiuhua Wang, Maoping Pu, Caiyou Chen, Peng Yang, Yun-Dong Wu, Yonggui Robin Chi, and Jianrong Steve Zhou*. Nickel-Catalyzed Enantioselective Reductive Arylation and Heteroarylation of Aldimines via an Elementary 1,4-Addition, J. Am. Chem. Soc. 2023, 145, 8498–8509. (Equal contribution; One of the most read articles of JACS in the month;) (IF 16.383)

2. Luoqiang Zhang, Daoyong Zhu, Jingyao Hu, Minjun Feng, Tze Chien Sum, Haoran Sun, Hajime Hirao, Yonggui Robin Chi, and Jianrong Steve Zhou*, Pursuing High Efficiency in Photocatalytic Oxidative Couplings of Heteroarenes and Aliphatic CH bonds, Org. Chem. Front. 2023, 10, 1651–1659. (Equal contribution) (IF 5.456)

3. Luoqiang Zhang, Mengxin Zhao, Maoping Pu, Zhaoming Ma, Jingsong Zhou, Caiyou Chen, Yun-Dong Wu, Yonggui Robin Chi, and Jianrong Steve Zhou*. Nickel-Catalyzed Enantioselective Reductive Conjugate Arylation and Heteroarylation via an Elementary Mechanism of 1,4-Addition, J. Am. Chem. Soc. 2022, 144, 20249-20257. (Equal contribution; One of the most read articles of JACS in the month; Highlighted by Chin. J. Org. Chem. 2022, 42, 4362-4363) (IF 16.383)

4. Luoqiang Zhang, Yanbing Wang, Yang Shi, Yimin Wu, Jingbo Lan*, Weixin Ma, and Jingsong You*. Highly Regio- and Chemoselective Oxidative C−H/C−H Cross-Couplings of Anilines and Phenols Enabled by a Co-Oxidant-Free Rh(I)/Zn(NTf2)2/Air Catalytic System, ACS Catal. 2019, 9, 5358−5364. (IF 13.7)

5. Luoqiang Zhang, Lei Zhu, Yuming Zhang, Yudong Yang, Yimin Wu, Weixin Ma, Yu Lan*, and Jingsong You*. Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C−H/C−H Coupling of Phenols with Aromatic Amides Using Air as Oxidant: Scope, Synthetic Applications and Mechanistic Insights, ACS Catal. 2018, 8, 8324−8335. (IF 13.7)

6. Luo-Qiang Zhang, Shiping Yang, Xiaolei Huang, Jingsong You, and Feijie Song*. Aerobic Ru-catalyzed Direct C2-Olefination of N-Heteroarenes with Alkenes Directed by a Removable N-Dimethylcarbamoyl Group, Chem. Commun. 2013, 49, 8830−8832. (IF 6.065)

7. Guangying Tan, Luoqiang Zhang, Xingrong Liao, Yang Shi, Yimin Wu, Yudong Yang, and Jingsong You*. Copper- or Nickel-Enabled Oxidative Cross-Coupling of Unreactive C(sp3)−H Bonds with Azole C(sp2)−H Bonds: Rapid Access to βAzolyl Propanoic Acid Derivatives, Org. Lett. 2017, 19, 4830−4833. (Equal contribution) (IF 6.072)

8. Fei Wang, Luoqiang Zhang, Weiguo Han, Zhengyang Bin*, and Jingsong You*. Intramolecular C−H Activation as an Easy Toolbox to Synthesize Pyridine-Fused Bipolar Hosts for Blue Organic Light-Emitting Diodes, Angew. Chem. Int. Ed. 2022, 61, e202205380. (IF 16.823)

9. Weixin Ma, Luoqiang Zhang, Yang Shi, You Ran, Yang Liu, and Jingsong You*. Molecular Engineering to Access Fluorescent Trackers of Organelles by Cyclization: Chemical Environment of Nitrogen Atom‐Modulated Targets, Adv. Funct. Mater. 2020, 30, 2004511. (IF 19.924)

10. Xiaolei Huang, Minh Hieu Nguyen, Maoping Pu, Luoqiang Zhang, Yonggui Robin Chi, Yun-Dong Wu, and Jianrong Steve Zhou*. Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles, Angew. Chem. Int . Ed. 2020, 59, 10814–10818. (IF 16.823)

11. Zhiqian Yu, Yan Zhang, Junbin Tang, Luoqiang Zhang, Qianhui Liu, Qian Li, Ge Gao*, and Jingsong You*. Ir-Catalyzed Cascade C–H Fusion of Aldoxime Ethers and Heteroarenes: Scope and Mechanisms, ACS Catal. 2020, 10, 203–209. (IF 13.7)

12. Yang Shi, Luoqiang Zhang, Jingbo Lan*, Min Zhang, Fulin Zhou, Wenlong Wei, and Jingsong You*. Oxidative C−H/C−H Cross-Coupling Reactions between N-Acylanilines and Benzamides Enabled by a Cp*-Free RhCl3/TFA Catalytic System, Angew. Chem. Int. Ed. 2018, 57, 9108 –9112. (IF 16.823)

13. Yimin Wu, Wei Li, Linfeng Jiang, Luoqiang Zhang, Jingbo Lan, and Jingsong You*, Rhodium-Catalyzed ortho-Heteroarylation of Phenols: Directing Group-Enabled Switching of the Electronic Bias for Heteroaromatic Coupling Partner, Chem. Sci. 2018, 9, 6878–6882. (IF 9.969)

14. Chunxia Wang, Luoqiang Zhang, and Jingsong You*. Nickel-Catalyzed Aminoxylation of Inert Aliphatic C(sp3)−H Bonds with Stable Nitroxyl Radicals under Air: One-Pot Route to α‑Formyl Acid Derivatives, Org. Lett. 2017, 19, 1690−1693. (IF 6.072)

15. You Ran, Yudong Yang,* and Luoqiang Zhang. Sodium Chlorate as a Viable Substoichiometric Oxidant for Cobalt-Catalyzed Oxidative Annulation of Aryl Sulfonamides with Alkynes, Tetrahedron Lett. 2016, 57, 3322–3325. (IF 2.032)

16. Yang Liu, Yudong Yang,* Yang Shi, Xiaojie Wang, Luoqiang Zhang, Yangyang Cheng, and Jingsong You*. Rhodium-Catalyzed Oxidative Coupling of Benzoic Acids with Terminal Alkynes: An Efficient Access to 3-Ylidenephthalides, Organometallics 2016, 35, 1350−1353. (IF 3.837)

17. Zhijie She, Yangyang Cheng, Luoqiang Zhang, Xiaoyu Li, Di Wu, Qiang Guo, Jingbo Lan*, Ruilin Wang*, and Jingsong You*. Novel Ruthenium Sensitizers with a Phenothiazine Conjugated Bipyridyl Ligand for High-Efficiency Dye-Sensitized Solar Cells, ACS Appl. Mater. Interfaces 2015, 7, 27831−27837. (IF 10.383)

Guangying Tan, Xiaolei Huang, Qian Wu, Luo-Qiang Zhang, and Jingsong You*. Rh(III)-Catalyzed Annulation of N-Methoxybenzamides with Ynesulfonamides at Room Temperature: A Practical and Efficient Route to 4-Aminoisoquinolone Derivatives, RSC Adv. 2014, 4, 49186–49189. (IF 4.036)

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