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蒋静文

博士 研究员 博士生导师
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基本情况

2019年毕业于四川大学生物治疗国家重点实验室,获理学博士学位,随后在四川大学华西医院从事博士后研究;20231月起任四川大学华西公共卫生学院特聘研究员,博士生导师。长期从事代谢重塑在肿瘤发生发展中的机制研究与营养干预策略挖掘,筛选并鉴定了多个代谢相关分子作为潜在肿瘤诊疗靶标; 旧药新用为切入点,发现了多个药物的抗肿瘤新适应证,明确了其作用靶点及抗肿瘤机制。以第一/通讯作者(含共同)在包括Signal Transduct Target TherAutophagyNat CommunAdv Sci(封面论文)、EMBO Mol MedDrug Resist Updat(高被引)、Trends Biochem Sci(高被引)、Cell RepPhytomedicineAntioxid Redox Signal等期刊发表论文27篇,大于1015篇,论文总引用2,000余次。主持国家自然科学基金面上项目、青年项目;四川省杰出青年科技人才项目;入选四川大学双百人才(B)、获四川大学优秀科研人才奖。

联系方式:jjwcn@foxmail.com;jjwcn@scu.edu.cn

工作经历

2023/1至今 四川大学,华西公共卫生学院/华西第四医院,特聘研究员

2019/9–2022/12,四川大学,华西医院,博士后,副研究员

招生方向

1.公共卫生与预防医学;2.生物化学与分子细胞生物学;3.药理学;4.基础医学。

研究方向(含承担课题)

1. 肿瘤代谢、免疫与肿瘤发生发展机制研究

2. 抗肿瘤药物筛选、靶点鉴定及机制研究

3. 营养干预在肿瘤治疗中的作用及机制研究

科研成果

主持或承担的项目:

1. 自然科学基金委面上基金,2024-2027,主持

2. 自然科学基金委青年基金,2021-2023,主持

3. 四川省杰出青年基金,2025-2027,主持

4. 四川大学01”创新研究项目,2023-2025,主持

5. 四川大学引进人才基金,2023-2026,主持

著作论文

1.       Xie X*, Lian S*, Yang W*, He S, He J, Wang Y, Zeng Y, Lu F, Jiang J#. Natural products for the treatment of age-related macular degeneration: New insights focusing on mitochondrial quality control and cGAS/STING pathway. J Pharm Anal. 2025. 15(5) 101145.IF8.9

2.       Liu H*, Yang W#Jiang J#. Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity. J Pharm Anal. 20 November 2024, 101150.IF8.9

3.       Wang Y*, He J*, Lian S, Zeng Y, He S, Xu J, Luo L, Yang W#Jiang J#. Targeting Metabolic-Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy. Antioxidants (Basel). 2024 Jul 10;13(7):828.IF6.6

4.       Wang Y*, Zeng Y*, Yang W*, Wang X* and Jiang J#, Targeting CD8+ T cells for anti-tumor effects: mechanistic insights into natural products. Phytomedicine. 2024 Apr 8:129:155608. IF8.3

5.       Luo L*, Wu X*, Fan J*, Dong L, Wang M, Zeng Y, Li S, Yang W, Jiang J#, Wang K#FBXO7 Ubiquitinates PRMT1 to Suppress Serine Synthesis and Tumor Growth in Hepatocellular CarcinomaNat Commun. 2024 Jun 5;15(1):4790.IF15.7

6.       Duan J*, Huang Z*, Qin S*, Li B, Zhang Z, Liu R, Wang K, Nice EC, Jiang J#, Huang C#. Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumor growth in experimental hepatocellular carcinoma. J Extracell Vesicles. 2024;13(7):e12468. IF14.5

7.       Li B, Ming H, Qin S, Zhou L, Huang Z, Jin P, Peng L, Luo M, Zhang T, Wang K, Liu R, Liou YC, Nice EC, Jiang J#, Huang C#. HSPA8 activates Wnt/β-catenin signaling to facilitate BRAF V600E colorectal cancer progression by CMA-mediated CAV1 degradation. Adv Sci. 2024 Jan;11(3):e2306535.IF15.1

8.       Jiang J*, Chen HN*, Jin P*Zhou L, Peng L, Huang Z, Qin S, Li B, Ming H, Luo M, Xie N, Gao W, Nice EC, Yu Q, Huang C#. Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant. Signal Transduct Target Ther. 2023 Feb 15;8(1):65.IF52.7

9.       Jin P*Jiang J*, Zhou L, Huang Z, Qin S, Chen HN, Peng L, Zhang Z, Li B, Luo M, Zhang T, Ming H, Ding N, Li L, Xie N, Gao W, Zhang W, Nice EC, Wei Y, Huang C#. Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis. EMBO Mol Med2022 Dec 7;14(12):e16082.IF11.1

10.   Zhou L*Jiang J*, Huang Z*, Jin P, Peng L, Luo M, Zhang Z, Chen Y, Xie N, Gao W, Nice EC, Li J#, Chen H#, Huang C#. Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA. Mol Cancer. 2022;21(1):168.IF37.3

11.   Jin P*Jiang J*, Zhou L*, Huang Z, Nice EC, Huang C#, Fu L#. Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. J Hematol Oncol. 2022 Jul 18;15(1):97.IF28.5

12.   Jiang J*, Peng L*, Wang K#, Huang C#Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code. Antioxid Redox Signal. 2021 May 1;34(13):979-1003.IF6.6

13.   Jiang J*, Zhang L*, Chen HN, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K#, Huang C#. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy. 2020; 16(1):106-22.IF13.3

14.   Jiang J*, Wang K*, Chen Y*, Chen H, Nice EC, Huang C. Redox regulation in tumor cell epithelial-mesenchymal transition: molecular basis and therapeutic strategy. Signal Transduct Target Ther. 2017 Aug 18;2:17036. (IF52.7)

15.   Wang K*Jiang J*, Lei Y, Zhou S, Wei Y, Huang C#Targeting Metabolic-redox Circuits for Cancer Therapy. Trends Biochem Sci. 2019; 44(5):401-414.IF13.8

16.   Li B*Jiang J*, Assaraf YG, Xiao H, Chen Z-S#, Huang C#. Surmounting Cancer Drug Resistance: New Insights from the perspective of N6-Methyladenosine RNA Modification. Drug Resist Updat. 2020; 53:100720.IF24.3

17.   Qin S*Jiang J*, Lu Y, Nice EC, Huang C#, Zhang J#, He W#. Emerging role of tumor cell plasticity in modifying therapeutic response. Signal Transduct Target Ther. 2020; 5(1):228.IF52.7

 

18.   Peng L*, Jiang J*, Chen HN, Zhou L, Huang Z, Qin S, Jin P, Luo M, Li B, Shi J, Xie N, Deng LW, Liou YC, Nice EC, Huang C#, Wei Y. Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer. Cell Rep. 2021 Nov 30;37(9):110069.IF9.995

学术兼职

1. 任中国药理学会化疗药理专业委员会青年委员

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