2020年博士毕业于四川大学华西医院生物治疗全国重点实验室。从事肿瘤发生发展的分子机制研究，发表论文10余篇，获国家自然科学基金、中国博士后科学基金、四川省科技计划等项目资助。

邮箱：huangzhao@scu.edu.cn

2021/03-2024/03 四川大学华西医院生物治疗全国重点实验室 助理研究员

2024/09-今 四川大学华西公共卫生学院/华西第四医院 特聘副研究员

肿瘤发生发展的分子机制

承担课题：

国家自然科学基金青年科学基金项目（82103168），PDLIM5通过下调EIF2B4 m6A修饰抑制肝癌发生的分子机制研究，执行期：2022.01 - 2024.12，30万，主持。

围绕肿瘤发生发展的分子机制开展了一系列相关研究。以第一作者（含共同）发表的论文出版于Adv Sci、Hepatology（2篇）、Mol Cancer（2篇）、Signal Transduct Target Ther、Oncogene、J Extracell Vesicles、Drug Resist Updat等国际学术研究杂志。其中，发现RNF25是一个新的E-cadherin E3泛素连接酶，以不依赖于传统的DNA甲基化介导的表观遗传沉默机制，诱导E-cadherin蛋白泛素化降解促进肝癌转移（Adv Sci. 2024）。此外，还发现支架蛋白PDLIM1通过竞争性结合ACTN4，限制F-actin的过度生长，维持Hippo通路处于激活状态，抑制YAP诱导的肝癌转移（Hepatology. 2020）。基于上述发现，受邀撰写肿瘤研究领域相关综述（Mol Cancer. 2020，ESI高被引论文；Signal Transduct Target Ther. 2021, ESI高被引论文）。

1. He B, Huang Z, Qin S, Peng P, Duan X, Wang L, Ye Q, Wang K, Jiang J, Li B, Liu R, Huang C. Enhanced SLC35B2/SAV1 sulfation axis promotes tumor growth by inhibiting Hippo signaling in HCC. Hepatology. 2025 Feb 1;81(2):436-452.

2. Huang Z, Zhou L, Duan J, Qin S, Jiang J, Chen H, Wang K, Liu R, Yuan M, Tang X, Nice EC, Wei Y, Zhang W, Huang C. Oxidative Stress Promotes Liver Cancer Metastasis via RNF25-Mediated E-Cadherin Protein Degradation. Adv Sci (Weinh). 2024 Apr;11(13):e2306929.

3. Duan J, Huang Z, Qin S, Li B, Zhang Z, Liu R, Wang K, Nice EC, Jiang J, Huang C. Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma. J Extracell Vesicles. 2024 Jul;13(7):e12468.

4. Jia W, Huang Z, Zhou L, Liou YC, Di Virgilio F, Ulrich H, Illes P, Zhang W, Huang C, Tang Y. Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies. Drug Resist Updat. 2023 Sep;70:100988.

5. Zhou L, Jiang J, Huang Z, Jin P, Peng L, Luo M, Zhang Z, Chen Y, Xie N, Gao W, Nice EC, Li JQ, Chen HN, Huang C. Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA. Mol Cancer. 2022 Aug 19;21(1):168.

6. Huang Z, Zhang Z, Zhou C, Liu L, Huang C. Epithelial-mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities. MedComm (2020). 2022 May 18;3(2):e144.

7. Luo M, Huang Z, Yang X, Chen Y, Jiang J, Zhang L, Zhou L, Qin S, Jin P, Fu S, Peng L, Li B, Fang Y, Pu W, Gong Y, Liu Y, Ren Z, Liu QL, Wang C, Xiao F, He D, Zhang H, Li C, Xu H, Dai L, Peng Y, Zhou ZG, Huang C, Chen HN. PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2022;13(4):1223-1242.

8. Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y. From purines to purinergic signalling: molecular functions and human diseases. Signal Transduct Target Ther. 2021 Apr 28;6(1):162.

9. Liu J, Huang Z, Chen HN, Qin S, Chen Y, Jiang J, Zhang Z, Luo M, Ye Q, Xie N, Zhou ZG, Wei Y, Xie K, Huang C. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer. Oncogene. 2021 May;40(19):3394-3407.

10. Huang Z, Zhou JK, Peng Y, He W, Huang C. The role of long noncoding RNAs in hepatocellular carcinoma. Mol Cancer. 2020 Apr 15;19(1):77.

11. Huang Z, Zhou JK, Wang K, Chen H, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Huang C, Wei X, Peng Y. PDLIM1 Inhibits Tumor Metastasis Through Activating Hippo Signaling in Hepatocellular Carcinoma. Hepatology. 2020 May;71(5):1643-1659.

Huang Z, Zhou L, Chen Z, Nice EC, Huang C. Stress management by autophagy: Implications for chemoresistance. Int J Cancer. 2016 Jul 1;139(1):23-32.