讲授《分子生物学检验技术》、《细菌学检验》、《卫生微生物》、《卫生微生物实验》、《病原微生物检验实验》、《文明之痕流行病与公共卫生》等本科生课程，任研究生《同一健康与检验》课程负责人、国家规划教材《细菌学检验》编委、副主编（数字版），获 “人卫杯”全国高等学校卫生检验青年教师竞赛特等奖、优秀课件奖，四川大学教师教学创新竞赛二等奖，学院教学创新竞赛一等奖、四川省微生物年会暨首届呼吸道感染与防治学术会议优秀报告奖，四川省微生物学会优秀党员，四川大学课堂教学质量优秀奖。指导国家级、省级等大学生创新创业项目10项，获省级卫检技能竞赛优秀指导教师，“一流卫生检验本科人才培养”国家级教学成果二等奖（主研，有证书）。

2021.09-至今，   四川大学华西公共卫生学院，副教授

2019.07-2021.08，四川大学华西公共卫生学院，特聘副研究员

2014.12-2019.07，哈佛医学院/波士顿儿童医院，博士后

2012.07-2014.11，中国科学院成都生物研究所，助理研究员

研究领域为分枝杆菌的致病机制，耐药机制及防治策略。

主持教育部产学合作协同育人项目、四川大学教学改革、教材建设项目及国家自然科学基金、四川大学引进人才科研基金、四川省重点实验室课题等项目10余项，发表SCI论文40余篇，获国家授权专利6项、教育部科技奖励二等奖1项（主研，有证书）。

发表论文 (*通讯作者, ^#同等贡献作者)

第一作者或通讯作者：

1) Discovery of novel reversible inhibitor of DprE1 based on benzomorpholine for the treatment of tuberculosis. Xiang W, He H, Duan X, He Z, Xu X, Liao M, Teng F, Li X, Luo T, Zeng J*, Yu L*, Gao C*. Microbiol Spectr. 2023 Sep 12:e0472122.

2) Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans. Zheng T, Jing M, Gong T, Yan J, Wang X, Xu M, Zhou X, Zeng J*, Li Y*. J Oral Microbiol. 2023 Jun 18;15(1):2225257.

3) vicR overexpression in Streptococcus mutans causes aggregation and affects interspecies competition. Yan J, Gong T, Ma Q, Zheng T, Chen J, Li J, Jing M, Lin Y, Wang X, Lei L, Wang S, Zeng J*, Li Y*. Mol Oral Microbiol. 2023 Jun;38(3):224-236.

4) Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases. Wang Y, Xu S, He Q, Sun K, Wang X, Zhang X, Li Y*, Zeng J*.  Front Microbiol. 2023 Apr 13;14:1151552.

5) Effect of Panax quinquefolius extract on Mycobacterium abscessus biofilm formation. He Z, Xu X, Wang C, Li Y, Dong B, Li S, Zeng J*.  Biofouling. 2023 Jan; 39(1):24-35.

6) Anti-tuberculosis drug development via targeting the cell envelope of Mycobacterium tuberculosis. Xu X, Dong B, Peng L, Gao C, He Z, Wang C, Zeng J*. Front Microbiol. 2022 Dec 21;13:1056608.

7) Improved Conventional and New Approaches in the Diagnosis of Tuberculosis. Dong B, He Z, Li Y, Xu X, Wang C, Zeng J*. Front Microbiol. 2022 May;13:924410.

8)  Deletion of the yqeK gene leads to the accumulation of Ap4A and reduced biofilm formation in Streptococcus mutans. Zheng T, Jing M, Gong T, Yan J, Zeng J*, Li Y*.  Mol Oral Microbiol. 2022 Feb;37(1):9-21.

9) Ursolic acid inhibits multi-species biofilms developed by Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii. Lyu X, Wang L, Shui Y, Jiang Q, Chen L, Yang W, He X, Zeng J*, Li Y*. Arch Oral Biol. 2021 May;125:105107.  

10) Quantitative acetylome analysis reveals involvement of glucosyltransferase acetylation in Streptococcus mutans biofilm formation. Lei L#, Zeng J#, Wang L, Gong T, Zheng X, Qiu W, Zhang R, Yun L, Yang Y*, Li Y*.  Env Microbiol Rep. 2021 Apr;13(2):86-97

11) Activity of Ligustrum robustum (Roxb.) Blume extract against the biofilm formation and exopolysaccharide synthesis of Streptococcus mutans. Zhang Z#, Zeng J#, Zhou X, Xu Q, Li C, Liu Y, Zhang C, Wang L, Zeng W, Li Y*. Mol Oral Microbiol. 2021 Feb;36(1):67-79.

12) Shared bicycle microbial community: A Potential antibiotic-resistant bacteria warehouse. Wu Y, Xie J, Li J, Zhao J, Qiao S, Li Y*, Zeng J*. Folia Microbiol (Praha). 2021 Feb;66(1):49-58.

13) Comprehensive profiling of protein lysine acetylation and its overlap with lysine succinylation in the Porphyromonas gingivalis fimbriated strain ATCC 33277. Zeng J#, Wu L#, Chen Q, Wang L, Qiu W, Zheng X, Yin X, Liu J, Ren Y, Li Y*.  Mol Oral Microbiol. 2020 Dec;35(6):240-250.

14) Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility. Zeng J, Platig J, Cheng TY, Ahmed S, Skaf Y, Potluri LP, Schwartz D, Steen H, Moody DB, Husson RN *. PLoS pathog. 2020 Apr 7;16(4):e1008452.

15) Rhodiola rosea extract inhibits the biofilm formation and the expression of virulence genes of cariogenic oral pathogen Streptococcus mutans. Zhang Z, Liu Y, Lu M, Lyu X, Gong T, Tang B, Wang L, Zeng J*, Li Y*. Arch Oral Biol. 2020 Aug. 116:104762.

16) Novel drug resistance and gene transfer mechanisms in respiratory/oral bacteria. Jiang S#, Zeng J#, Zhou X, Li Y*. J Dent Res. 2018 Sep Vol. 97(10) 1092–1099.

17) Interaction between rpsL and gyrA mutations affects the fitness and dual-resistance of Mycobacterium tuberculosis clinical isolates against streptomycin and fluoroquinolone. Sun H#, Zeng J#, Li S, Liang P, Zheng C, Liu Y, Luo T, Rastogi N, Sun Q*. Infect Drug Resist. 2018. Mar 27;11:431-440. 

18) Solution scattering study of the Bacillus subtilis PgdS enzyme involved in poly-γ-glutamic acids degradation. Zeng J, Jin Y, Liu Z*. PLoS One. 2018. Apr 2;13(4):e0195355.

19) Anti-tuberculosis drug target discovery by targeting the higher in-degree proteins (HidPs) of the pathogen’s transcriptional network. Cui T#, Zeng J#, He ZG*. J Tuberc 2018 Mar 05, 1: 1001.

20) A genome-wide regulator-DNA interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. Zeng J, Cui T, He ZG*. J Proteome Res. 2012. Sep 7;11(9):4682-92.

21) A novel high-throughput B1H-ChIP method for efficiently validating and screening specific regulator-target promoter interactions. Zeng J, Li Y, Zhang S, He ZG*. Appl Microbiol Biotechnol. 2012. Feb;93(3):1257-69.

22) Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Zeng J, Zhang L, Li Y, Wang Y, Wang M, Duan X, He ZG*. Protein Expr Purif. 2010. Jan;69(1):47-53.  

23) A New Bacterial Co-expression System for Over-expressing Soluble Protein and Validating Protein-protein Interaction. Zeng J, He ZG*. Methods Mol Biol. 2012. 2012;824:235-49.  (英文著作)

24)  东宝瑜，许馨月，李树华，李帅，曾雪婷，王雨萌，孙琨，汪 川，曾菊梅*. 黄芩提取物对脓肿分枝杆菌生长及生物膜形成的影响[J]. 四川大学学报: 自然科学版，2023，60: 046003.

25)  李雨含，李嘉鑫，张诗铭，张耀华，李雨庆*，曾菊梅*. 变异链球菌噬菌体的研究进展及其在龋病防控中的应用前景，口腔疾病防治，2021年29卷3期 184-188页

合作者论文：

1) Lin Y, Ma Q, Yan J, Gong T, Huang J, Chen J, Li J, Qiu Y, Wang X, Lei Z, Zeng J, Wang L, Zhou X, Li Y*. Inhibition of Streptococcus mutans growth and biofilm formation through protein acetylation. Mol Oral Microbiol. 2024 Jan 15.

2) Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors. Zhang J, Sui J, Huang J, Qiu Z, Zhang X, Zeng J, Bai L, Bao R, Luo Y*. J Med Chem. 2023 Dec 28;66(24):16597-16614.

3) Membrane vesicles derived from Listeria monocytogenes might be a potential antigen delivery vector. Tang M, Tian S, Chen K, Zhang Q, Lei Y, Tang T, Zeng J, Wang C*.  Int J Pharm. 2023 Sep 25;644:123275.

4) Network pharmacology- and molecular simulation-based exploration of therapeutic targets and mechanisms of heparin for the treatment of sepsis/COVID-19. Fang Y, Lin S, Dou Q, Gui J, Li W, Tan H, Wang Y, Zeng J, Khan A, Wei DQ*. J Biomol Struct Dyn. 2023 Jan 20:1-13.

5) Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors. Li C, Liu S, Dong B, Li C, Jian L, He J, Zeng J, Zhou Q, Jia D, Luo Y*, Sun Q*. J Med Chem. 2022 Aug 25;65(16):11058-11065.

6) Combined transcriptomic and metabolomic analysis of Salmonella in the presence or absence of PhoP-PhoQ system under low Mg2+ conditions. Li Y, Tian S, Yang L, Bao X, Su L, Zhang X, Liu S, Zhu Y, Yang J, Lin H, Zhang J, Zeng J, Wang C, Tang T*. Metabolomics. 2022 Nov 15;18(11):93.

7) Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response. Barth VC, Chauhan U, Zeng J, Su X, Zheng H, Husson RN, Woychik NA*.  Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2022136118.

8) Heterologous Boosting With Listeria-Based Recombinant Strains in BCG-Primed Mice Improved Protection Against Pulmonary Mycobacterial Infection. Liu S, Tian S, Zhang Y, Tang T, Zeng J, Fan X, Wang C*. Front Immunol. 2020 Sep 2;11:2036.

9) Intrinsic Fluoride Tolerance Regulated by a Transcription Factor. Lu M, Xiang Z, Gong T, Zhou X, Zhang Z, Tang B, Zeng J, Wang L, Cui T, Li Y*.  J Dent Res. 2020. Oct;99(11):1270-1278.

10) CRISPR-Cas systems in oral microbiome: from immune defense to physiological regulation. Gong T, Zeng J, Tang B, Zhou X*, Li Y*. Mol Oral Microbiol. 2020. Apr;35(2):41-48.

11) Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host. Cintrón M, Zeng J, Barth VC, Cruz J, Husson RN, and Woychik NA*. Sci Rep. 2019. Apr 11;9(1):5949.

12) Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome. Barth VC, Zeng J, Vvedenskaya IO, Ouyang M, Husson RN and Woychik NA*. Nat Commun. 2019. Jul 10;10(1):3035.

13) Global Analysis of Lysine Succinylome in the Periodontal Pathogen Porphyromonas gingivalis. Wu L, Gong T, Zhou X, Zeng J, Huang R, Wu Y, Li Y*. Mol Oral Microbiol. 2019. Apr;34(2):74-83.

14) A GntR Family Transcription Factor in Streptococcus mutans Regulates Biofilm Formation and Expression of Multiple Sugar Transporter Genes. Li Z, Xiang Z, Zeng J, Li Y, Li J* Front Microbiol. 2019. Jan 14;9:3224.

15) EzrA, a cell shape regulator contributing to biofilm formation and competitiveness in Streptococcus mutans. Xiang Z, Li Z, Ren Z, Zeng J, Peng X, Li Y, Li J*.  Mol Oral Microbiol. 2019. Oct;34(5):194-208.  

16) Regulation of Cell Division in Streptococci: Comparing with the Model Rods. Xiang Z, Li Z, Zeng J, Li Y, Li J*.  Curr Issues Mol Biol. 2019. 32:259-326.

17) Deletion of cas3 gene in Streptococcus mutans affects biofilm formation and increases fluoride sensitivity. Tang B, Gong T, Zhou X, Lu M, Zeng J, Peng X, Wang S, Li Y*. Arch Oral Biol. 2019. Mar;99:190-197.

18) Genome editing in Streptococcus mutans through self-targeting CRISPR arrays. Gong T, Tang B, Zhou X, Zeng J, Lu M, Guo X, Peng X, Lei L, Gong B, Li Y*. Mol Oral Microbiol. 2018. Dec;33(6):440-449. 

19) Inhibition of Enterococcus faecalis Growth and Biofilm Formation by Molecule Targeting Cyclic di-AMP Synthetase Activity. Chen L, Li X, Zhou X, Zeng J, Ren Z, Lei L, Kang D, Zhang K, Zou J, Li Y*. J Endod. 2018. Sep;44(9):1381-1388.e2.  

20) Multi-systems analysis of Mycobacterium tuberculosis reveals kinase-dependent remodeling of the pathogen-environment interface.Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Madduri AVR, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN*. mBio. 2018. Mar 6;9(2):e02333-17.

21) Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition. Liu N, Flanagan P, Zeng J, Jani N, Cardenas ME, Moran GP, Köhler JR*. Proc Natl Acad Sci U S A. 2017. Jun 13;114(24):6346-6351.

22) Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in Streptococcus mutans. Cheng X, Zheng X, Zhou X, Zeng J, Ren Z, Xu X, Cheng L, Li M, Li J, Li Y*. Environ Microbiol. 2016. Mar;18(3):904-22.

23) Inhibition of Streptococcus mutans biofilm formation, extracellular polysaccharide production, and virulence by an oxazole derivative. Chen L, Ren Z, Zhou X, Zeng J, Zou J, Li Y*. Appl Microbiol Biotechnol. 2016. Jan;100(2):857-67.  

24) Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence. Ren Z, Cui T, Zeng J, Chen L, Zhang W, Xu X, Cheng L, Li M, Li J, Zhou X, Li Y*. Antimicrob Agents Chemother. 2015. Oct 19;60(1):126-35.

25) A Proteome-Scale Identification of Novel Antigenic Proteins in Mycobacterium tuberculosis toward Diagnostic and Vaccine Development. Li Y,

全国公共卫生与预防医学名词审定委员会卫生检验学分委会秘书长，四川省海外高层次留学人才，四川省特聘专家，四川省微生物学会常务理事、基础微生物专委会副主任，中国防痨协会学校与儿童结核病防治分委会常务委员。