导航菜单
基本情况
2012年博士毕业于美国Auburn大学化学与生物化学系。致公党党员，致公党成都市委华西支部副主委，致公党成都市委科技教育服务委员会执行主任，成都欧美同学会理事，食品安全监测与风险评估四川省重点实验室PI，四川大学健康食品科学评价中心PI，四川省卫健委学术技术带头人后备，四川省海外高层次留学人才，成都天府海智计划专家。十余年来，从事公共卫生与预防医学一线教学科研工作，担任2017级卫生检验与检疫专业班主任、2024级预防医学专业班主任，指导多名本科生获国家级大学生创新创业训练计划立项并发表SCI论文，指导本科生获第十届全国大学生基础医学创新研究暨实验设计论坛校赛预防医学赛道一等奖，2023年以主要完成人获国家级教学成果二等奖。擅长将人群研究与实验室机制探索结合，关注环境与膳食因素对儿童、孕妇和老年人群的健康效应，作为负责人主持国家自然科学基金等多项国家级和省部级科研项目，并作为骨干承担科技部重点研发计划。近年来，以第一或通讯作者发表SCI收录论文40余篇，2024年以第二完成人获四川省科技进步二等奖。
工作经历
2013/04-2018/08， 四川大学华西公共卫生学院实验中心常务副主任，副研究员
2018/09-2022/07，四川大学华西公共卫生学院实验中心常务副主任，副教授（2019-2020苏州工业园区独墅湖科教创新区副主任）
2022/08-至今，四川大学华西公共卫生学院实验中心，副教授
研究方向(含承担课题)
结合多种人群和实验室研究方法，探索环境与膳食因素对青春期发育、内分泌代代谢病、心理和精神疾病、衰老和神经退行性疾病的效应及机制。
科研成果
1. 主持国家自然科学基金青年项目，81402642
2. 主持四川省自然科学基金面上项目，25NSFSC2411
3. 主持教育部留学回国科研基金，2013-1792-9-7
4. 主持四川省科技厅应用基础项目，2021YJ0156
5. 主持蒲江县健康素养促进评估调查研究服务项目，H210609
6. 主持金堂县健康促进县基线评估调查项目，H210714
7. 承担国家重点研发计划主动健康和人口老龄化科技应对专项课题，2020YFC2006301
8. 承担国家自然科学基金面上项目，82173512
9. 承担国家自然科学基金青年项目，81502768
10. 承担四川省科技厅应用基础项目，2015JY0212
著作论文
近年代表作（第一或通讯作者）
1. Zhou S, Xu Y, Xiong J*, Cheng G*. Cross-trait multivariate GWAS confirms health implications of pubertal timing. Nat Commun. 2025; 16(1): 799. doi: 10.1038/s41467-025-56191-4. (共同通讯, A-)
2. Zhou S, Zi J, Hu Y, Wang X, Cheng G*, Xiong J*. Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disorders. J Affect Disord. 2025; 374: 84-90. doi: 10.1016/j.jad.2025.01.048. (共同通讯, C)
3. Luo H#, Zhao S#, Zi J, Hu Y, Yao Y*, Xiong J*. Benzo[b]fluoranthene damages coronary artery and affects atherosclerosis markers in mice and umbilical vein endothelial cells. Toxicol Lett. 2024; 401: 150-157. doi: 10.1016/j.toxlet.2024.10.007. (共同通讯, C)
4. Li H, Zeng Y, Zi J, Hu Y, Ma G, Wang X, Shan S, Cheng G*, Xiong J*. Dietary Flavonoids Consumption and Health: An Umbrella Review. Mol Nutr Food Res. 2024; 68(12): e2300727. doi: 10.1002/mnfr.202300727. (共同通讯, C)
5. Tian Y, Zi J, Hu Y, Zeng Y, Li H, Luo H, Xiong J*. Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases. Depress Anxiety. 2024; 2024: 5515448. doi: 10.1155/2024/5515448. (独立通讯, B)
6. Tian Y#, Ma G#, Zi J, Hu Y, Zeng Y, Li H, Luo H, Shan S, Xiong J, Cheng G. Sex- and time-specific associations of obesity with glycaemic traits: A two-step multivariate Mendelian randomization study. Diabetes Obes Metab. 2024; 26(4): 1443-1453. doi: 10.1111/dom.15445. (独立通讯, C)
7. Ma G#, Tian Y#, Zi J, Hu Y, Li H, Zeng Y, Luo H, Xiong J*. Systemic inflammation mediates the association between environmental tobacco smoke and depressive symptoms: A cross-sectional study of NHANES 2009-2018. J Affect Disord. 2024; 348: 152-159. doi: 10.1016/j.jad.2023.12.060. (独立通讯, C)
8. Tian Y, Ma G, Li H, Zeng Y, Zhou S, Wang X, Shan S, Xu Y, Xiong J*, Cheng G. Shared genetics and comorbid genes of amyotrophic lateral sclerosis and Parkinson's disease. Mov Disord. 2023; 38(10): 1813-1821. doi: 10.1002/mds.29572. (独立通讯, B)
9. Ma G, Xu Y, Li H, Zeng Y, Wang X, Shan S, Xiong J*, Guo Cheng. Dietary factors and gestational diabetes mellitus: An umbrella review. Trends Food Sci Tech. 2023; 138: 229-237. doi: 10.1016/j.tifs.2023.06.010. (独立通讯, B)
10. Zhou S, Luo H, Tian Y, Li H, Zeng Y, Wang X, Shan S, Xiong J*, Cheng G. Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis. Psychol Med. 2023; 53(16): 7627-7635. doi: 10.1017/S0033291723001423. (独立通讯, B)
11. Tian Y, Shan S, Bao Q, Zhou S, Jiang X, Wang M, Yin S, Xiong J*, Cheng G. Identification of novel candidate genes in east Asian COPD patients by the functional summary-based imputation and the unified test for molecular signatures: a transcriptome-wide association study. Chin Med J. 2023; 136(13): 1612-1614. doi: 10.1097/CM9.0000000000002473. (独立通讯, B)
12. Zhou S, Tian Y, Song X, Xiong J*, Cheng G. Brain proteome-wide and transcriptome-wide association studies, Bayesian colocalization, and Mendelian randomization analyses reveal causal genes of Parkinson's disease. J Gerontol A Biol Sci Med Sci. 2023; 78(4): 563-568. doi: 10.1093/gerona/glac245. (独立通讯, B)
13. Xu Y, Shan S, Wang X, Li L, Ma L, Xiong J*, Fu P, Cheng G. Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway. Chin Med J. 2023; 136(19): 2368-2370. doi: 10.1097/CM9.0000000000002541. (独立通讯, B)
14. Zhou S, Ma G, Luo H, Shan S, Xiong J*, Cheng G. Identification of 5 potential predictive biomarkers for Alzheimer's disease by integrating the unified test for molecular signatures and weighted gene coexpression network analysis. J Gerontol A Biol Sci Med Sci. 2023; 78(4): 653-658. doi: 10.1093/gerona/glac179. (独立通讯, B)
15. Shan S, Zhou S, Ma G, Wang X, Xiong J*, Cheng G. Neuroprotective effect of hydroxy-α-sanshool against β-amyloid-induced damage in differentiated PC12 cells. Chin Med J. 2023; 136(17): 2140-2142. doi: 10.1097/CM9.0000000000002432. (独立通讯, B)
16. Xie L, Zhang X, Gao X, Wang L, Cheng Y, Zhang S, Yue J, Tang Y, Deng Y, Zhang B, He X, Tang M, Yang H, Zheng T, You J, Song X, Xiong J*, Zuo H*, Pei X. Microbiota and mycobiota in bronchoalveolar lavage fluid of silicosis patients. J Occup Med Toxicol. 2023; 18(1): 10. doi: 10.1186/s12995-023-00377-3. (共同通讯, D)
17. Bao Q, Zhao S, Liu Y, Yao Y, You J*, Xiong J*. Benzo[b]fluoranthene induced oxidative stress and apoptosis in human airway epithelial cells via mitochondrial disruption. J Appl Toxicol. 2023; 43(7): 1083-1094. doi: 10.1002/jat.4445. (共同通讯, D)
18. Zhao S, Bao Q, Ma G, Yao Y, Xie L*, Xiong J*. Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells. Toxicol In Vitro. 2023; 86: 105522. doi: 10.1016/j.tiv.2022.105522. (共同通讯, D)
19. Xu Y#, Xiong J#, Sun X*, Gao H*. Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy. Acta Pharm Sin B. 2022; 12(12): 4327-4347. doi: 10.1016/j.apsb.2022.11.001. (并列第一, B)
20. Xiong J, Tian Y, Ma G, Wang X, Shan S, Cheng G*. Impact of physiologically relevant genistein exposure at different time windows on puberty onset and neuroendocrine function in female rats. Mol Nutr Food Res. 2022; 66(24): e2200486. doi: 10.1002/mnfr.202200486. (独立第一, C)
21. Xiong J, Xu Y, Liu X, Wang X, Shan S, Crabbe MJC, Zhao L, Fang H, Cheng G. Prospective association of dietary soy and fibre intake with puberty timing: a cohort study among Chinese children. BMC Med. 2022; 20(1): 145. doi: 10.1186/s12916-022-02320-5. (独立第一, B)
22. Shi Y#, Shan S#, Li C, Song X, Zhang C, Chen J, You J*,Xiong J*. Application of the tumor site recognizable and dual-responsive nanoparticles for combinational treatment of the drug-resistant colorectal cancer. Pharm Res. 2020; 37(4): 72. doi: 10.1007/s11095-020-02791-2. (共同通讯, C)
23. Zhang S, Pei X, Xu Y, Xiong J*, Wang J*. Bio-safety assessment of carbon quantum dots, N-doped and folic acid modified carbon quantum dots: A systemic comparison. Chinese Chem Lett. 2020; 31(6): 1654-1659. doi: 10.1016/j.cclet.2019.09.018. (共同通讯, C)
24. Shan S#, Zheng T#, Zhang C, Song X, Chen J, Shi Y, You J, Cheng G*, Xiong J*. Yogurt and Streptococcus thermophilus metabolites ameliorated telomere attrition in D-galactose-induced ageing mice and t-BHP- challenged HepG2 cells. Int J Food Sci Tech. 2020; 55(6): 2509-2516. doi: 10.1111/ijfs.14502. (共同通讯, C)
25. Xiao W#, Xiong J#, Zhang S, Xiong Y, Zhang H, Gao H*. Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability. Int J Pharm. 2018; 538(1-2): 105-111. doi: 10.1016/j.ijpharm.2018.01.011. (并列第一, C)
26. Zhang Y, Gong Y, Xue H, Xiong J*, Cheng G*. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018; 125: 784-793. doi: 10.1111/1471-0528.15060. (共同通讯, C)
学术兼职
1. 中国营养学会营养流行病分会，委员
2. 中国优生科学协会小儿营养专业委员会，委员
3. 四川省营养学会青年委员会，常务委员
4. SCI期刊《Cellular and Molecular Biology》副主编
5. SCI期刊《Frontiers in Public Health》编委
荣誉奖励
1. 四川省科技进步二等奖（第二完成人）
2. 国家教学成果二等奖（主要完成人）
3. 四川大学华西公共卫生学院（华西第四医院）2024年教学先进个人
4. 四川大学华西公共卫生学院（华西第四医院）2022年科研先进个人
5. 江苏省委组织部第十二批科技镇长团优秀团员称号
6. 四川大学2019年十佳教师公共服务奖
7. 四川大学2018年全英语授课教学质量优秀奖
8. 美国亚拉巴马州高等教育委员会EPSCoR研究生科研奖
9. 第十七届国际核黄素与黄素蛋白研讨会（伯克利）青年研究者奖